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COSMOSIL HPLC Columns

 

Products|nacalai tesque, INC.                  COSMOSIL C18-PAQ|Products|nacalai tesque, INC.

 

COSMOSIL HPLC Columns

COSMOSIL Column List

Sample Separation Mode Packing Material USP Code Stationary
Phase
Special Features and Applications
Organic
Compounds
(low M.W.)
Reversed
Phase
3C18-EB L1 Octadecyl
Group
- Excellent for basic compounds
- 3 µm silica packing material
C18-MS-II L1 Octadecyl
Group
- Multi-purpose C18column
- Monofunctional silylation on ultra-pure silica gel for separation of the widest range of compounds
C18-AR-II L1 -Features strong acid resistance and suitable for acidic compounds and peptides
C18-PAQ L1 - Reversed phase column, compatible with 100% water based mobile phase.
- Suitable for hydrophilic compounds
Cholester - Cholesteryl
Group
- Usable under the same condition as C18
- Unique rigid cholesteryl structure improves separation
PFP  L43 Pentafluorophenyl
Group 
-Separation by
dipole-dipole
interactions.
πNAP - Naphtylethyl
Group
- Stronger π-π interaction than Phenyl column
PYE - Pyrenylethyl
Group
- Most powerful π-π interaction
NPE - Nitrophenylethyl
Group
- Separation utilizing π-π interaction and dipole-dipole interaction
PBr  Pentabromobenzyl group  - Separate hydrohilic compounds in reversed-phase conditions
PBB-R - Pentabromobenzyl
Group
- Separation utilizing dispersion force
C22-AR-II - Docosyl
Group
- Alkyl chain columns except C18column
C8-MS L7 Octyl
Group
C4-MS L26 Butyl
Group
TMS-MS L13 Trimethyl
Group
PE-MS L11 Phenylethyl
Group
- π-π interaction
CN-MS L10 Cyanopropyl
Group
- Great reproducibility using isocratic elution mode
Normal
Phase
SL-II L3 - - Suitable for preparative separation
Hydrophilic
Interaction
HILIC - Triazole - Retains highly polar compounds that would not be retained in C18column
Monosaccharides
Oligosaccharides
Hydrophilic
Interaction
Sugar-D - Secondary/Tertiary Amine - Suitable for monosaccharides, oligosaccharides
NH2-MS L8 Aminopropyl
Group
- Primary amine bonded column
Proteins Reversed
Phase
Protein-R - Octadecyl
Group
- Provides improved separation, high recovery rate, and acid resistance
C18-AR-300 L1 Octadecyl
Group
- Wide pore type reversed phase columns
C8-AR-300 L7 Octyl
Group
C4-AR-300 L26 Butyl
Group
Ph-AR-300 L11 Phenyl
Group
Proteins Gel
Permeation
Diol-120-II L20 Diol Group - Silica-based gel filtration column
Selection of pore size: 5,000-100,000
Diol-300-II L20 - Silica-based gel filtration column
Selection of pore size: 10,000-700,000
Ion-exchange Type Q   Quaternary Ammonium Type - Anion-exchange Type
- For Purification
- Target Sample: Acidic Proteins / DNA
Type Q-N   - Anion-exchange Type
- For Ultra-fast
Analysis, Precise
Analysis
- Target Sample: Acidic Proteins / DNA
Type S   Sulfopropyl Type - Cation-exchange Type
- For Purification
- Target Sample:
Basic Proteins
Type S-N   - Cation-exchange Type
- For Ultra-fast
Analysis, Precise
Analysis
- Target Sample:
Basic Proteins
Type M   Quaternary Ammonium Type/
Sulfopropyl Type
- Amphoteric ion-exchange Type
- For Purification
- Target Sample:
All Proteins
Type M-N   - Amphoteric ion-exchange Type
- For Precise
Analysis
- Target Sample:
All Proteins
Hydrophobic
Interaction
HIC - - - Suitable for separation of peptide, and there is only a little less in enzyme activity and the teriary structure of proteins
Fullerenes - Buckyprep - Pyrenylpropyl
Group
- Standard column for fullerene separation
Buckyprep-D
- Nitro-carbazoyl Group - Designed for separation of fullerene derivatives
Buckyprep-M - Phenothiazinyl
Group
- Designed to separate metallofullerenes
PBB - Pentabromobenzyl
Group
- Designed for preparative separation of C60, C70
PYE - Pyrenylethyl
Group
- Separation of Fullerenes and structural isomers
NPE - Nitrophenylethyl
Group
- Separation of derivatived fullerene
Carbon
Nanotubes
Gel
Permeation
CNT   Hydrophilic
Group
- separation of carbon nanotubes

Selection Guide

Organic Compounds (Low M.W.)

Octadecyl group bonded column (C18ODS) are recommended as first-choice columns for separations of organic compounds (Low M.W.). If there is not enough separation or no retention using COSMOSIL C18 columns, COSMOSIL series offer many kinds of special columns.

Organic compounds

Please click here for the selection guide for C18 columns

Saccharides
  • COSMOSIL Sugar-D is recommended for the separation of monosaccharides and oligosaccharides as a first-choice column.
  • For the separation of sugar derivatives, COSMOSIL C18-PAQ is suitable as well.
Proteins
  • Please select based on the separation mode.
Fullerenes
  • COSMOSIL Buckyprep is most suitable for the separation of fullerenes.
COSMOSIL Specilty Columns

USP Specifications

The USP (U.S. Pharmacopeia) specifications are listed below with the recommended COSMOSIL HPLC columns.

USP Code Description Recommended Columns
L1 Octadecyl silane chemically bonded to porous silica or ceramic micro-particles, 1.7 to 10 m in diameter, or a monolithic rod COSMOSIL C18-MS-II
COSMOSIL C18-AR-II
COSMOSIL C18-PAQ
COSMOSIL C18-AR-300
L3 Porous silica particles, 5 to 10 m in diameter COSMOSIL SL-II
L7 Octylsilane chemically bonded to totally porous silica particles, 1.7 to 10 m in diameter COSMOSIL C8-MS
COSMOSIL C8-AR-300
L10 Nitrile groups chemically bonded to porous silica particles, 3 to 10 m in diameter COSMOSIL CN-MS
L11 Phenyl groups chemically bonded to porous silica particles, 1.7 to 10 m in diameter COSMOSIL PE-MS
COSMOSIL Ph-AR-300
L13 Trimethylsilane chemically bonded to porous silica particles, 3 to 10 m in diamete COSMOSIL TMS-MS
L20 Dihydroxypropane groups chemically bonded to porous silica particles, 5 to 10 m in diameter COSMOSIL Diol-120-II
COSMOSIL Diol-300-II
L26 Butyl silane chemically bonded to totally porous silica particles, 3 to 10 m in diameter COSMOSIL C4-MS
COSMOSIL C4-AR-300

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